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Key Nutrient Depleted by Acetaminophen Glutathione the bodys primary antioxidant and detoxification molecule Why Glutathione Depletion Increases Liver Toxicity Risk Acetaminophen is metabolized in the liver through pathways that consume glutathione, a compound essential for neutralizing oxidative stress, detoxifying hormones and chemicals, and protecting cells from damage

In the GSH_c binding mode, residue 49 in the L1 region is within 4 of the ligand (Fig