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Interestingly, TDP-43 proteopathy is exacerbated in the presence of optineurin (OPTN) mutations, the genetic factor responsible for such accumulation (Thakur et al
Dulaglutide, a longacting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes
These findings suggest that therapies capable of blocking glutathione transport into organelles within the cell could help treat breast cancer
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