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Sixth, it is probable that real-world adherence to these medications would be lower than in the trials used to inform our study [9], although it should be noted that the scenario analyses with lower uptake did not substantially affect the ICER

In the trial groups of 1, 2, and 4, the individuals were instructed to limit their calorie intake and maintain a calorie deficit of 500 kcal per day

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

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