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Semax is generally considered well tolerated, but some users report side effects such as restlessness, irritability, or feeling more wired

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Although GLP-1RAs seem to have a beneficial influence in reversing many maladaptive brain changes relevant to depression, it should be remembered that at the same time, they are also known to mediate some unfavorable processes such as activation of the HPA axis and intensification of anxiety-like behavior in some animal studies