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Segn los estudios clnicos STEP, la prdida de peso contina progresivamente durante los primeros 12 a 18 meses de tratamiento, con resultados que varan entre los pacientes
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Endogenous GH secretion is itself a two-signal process: hypothalamic GHRH gates the pituitary's readiness, while ghrelin (the endogenous GHSR-1a ligand) provides the acute depolarizing signal
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