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Separately, significant weight loss and the muscle mass changes that sometimes accompany it can affect creatinine production (since creatinine is a byproduct of muscle metabolism)
Focus shifts to maintenance
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In fact, after six weeks of food restriction, db/db mice also had higher plasma glucose levels.[ref] Timing of Food: A recent mouse study found that eating during their inactive period (daytime for the mice, nighttime for us humans) caused leptin resistance and increased obesity and metabolic syndrome
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