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As a new hypoglycemic agent, GLP-1RA enhances insulin sensitivity, reduces body weight and protects the cardiovascular system (62)
The outcome also highlights the widening gap between consumer demand for peptide therapies and the conventional drug-development pathway
For semaglutide users, the evidence-based target is 1.2 to 1.6 grams per kilogram per day
In conclusion, the addition of semaglutide injections to lifestyle and metformin interventions can reduce BMI, waist and hip circumference, and body fat percentage, alleviate hyperandrogenemia, improve glucose metabolism and insulin resistance, and promote the restoration of normal menstrual cycles without exacerbating negative psychological emotions in individuals living with overweight/obesity and PCOS-related infertility
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