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Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 ( However, several counterarguments and challenges temper the translational optimism

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These pathways are modulated by diverse factors, including disease states, pharmacological inducers, cell regulatory programs, and iron chelators, ultimately converging on iron-dependent lipid peroxide accumulation and membrane damage ( There are several ways that ferroptosis can be initiated, with one being the introduction of inducers

Kerr, J