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Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38
These effects are more likely early in a protocol and often ease as the body adapts
The study also demonstrated a significant reduction in blood pressure, FPG, body mass index (BMI) and waist circumference at 12 weeks of treatment [60]
Yet that is simply not possible, nor will it ever be
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