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Clinical methods: the history, physical, and laboratory examinations Howard SC, McCormick J, Pui C-H, Buddington RK, Harvey RD (2016) Preventing and managing toxicities of high-dose methotrexate

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Stopping the medication should be a collaborative decision with your provider, not a unilateral one based on early side effects that might resolve

Most users receive starting doses below the maintenance level, allowing gradual adaptation to the drugs effects