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Evidence Summary No robust trial data demonstrating folate depletion attributable to GLP-1 therapy alone
Kidney Problems: In some cases, semaglutide can affect kidney function, especially in people who already have kidney issues
With GLP-1 medications specifically, this is well-studied enough that most prescribing doctors bring it up alongside protein intake
Temporary pauses for safety reasons: If something unexpected comes up, like illness, surgery, or hospitalization, the medication can be temporarily paused and then restarted later
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