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Changes in hormone stages can cause the manufacturing of more excellent sebum and plugged pores, which could cause zits
This can stain clothing or contact lenses, so take care (for example, consider using panty liners or easily washable undergarments in case urine drips are blue, and avoid wearing expensive light-colored clothing until you know it wont be stained)
(PubMed) Suh JH, Zhu BZ, deSzoeke E, Frei B, Hagen TM
This is accompanied by the upregulation of ER stress-related proteins, including PERK, IRE1, ATF4, CHOP, XBP-1 and ATF6
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