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The mechanism involves activation of the glucagon-like peptide-1 (GLP-1)/GLP-1 receptor axis within the islets, stimulating premature functional maturation of -cells through the Akt-mTORC1-pS6 pathway, thereby disrupting normal islet developmental timing
And according to a systematic review and meta-analysis published in Obesity Reviews , people who stopped GLP-1 therapy regained an average of 2.2 kg when coming off liraglutide and 9.7 kg when discontinuing semaglutide or tirzepatide
This is the core of the GLP-1 microbiome connection , in which SCFA production, microbial diversity, and mucosal integrity work together to support natural GLP-1 signaling
In addition, Saxenda and Wegovy carry a risk of acute pancreatitis, acute gallbladder disease, kidney problems like kidney failure, and suicidal thoughts or behaviors
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