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The most important unresolved safety-related research gaps include long-duration exposure, broader dose-response toxicology, sex-specific effects, reproductive and developmental endpoints, hematology, immune monitoring, genotoxicity assessment, and comprehensive off-target profiling across methyltransferase and non-methyltransferase targets
pseudotuberculosis and Y
Supporting Bone Density and Cardiovascular Health Estrogen helps keep bones strong, so declining levels during menopause increase the risk of osteoporosis
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