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Sikiric, P., Seiwerth, S., Grabarevic, Z., et al
Apigenin, curcumin, and resveratrol appear to attenuate oxidative stress- or chemotherapy-induced granulosa cells apoptosis, possibly by modulating apoptotic signaling pathways including the Bax/Bcl-2 ratio or inhibiting the caspase cascade (Fabov et al., 2023
For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges
Dorion et al
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