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However, other areas of the body can be used in specific circumstances
These differences could be explained by the study design (retrospective observational study vs prospective randomized trial), selection bias (subjects from the real-world clinical practice are less selected than those included in a clinical trial), drug compliance (subjects enrolled in a clinical trial perform several on site evaluation in which compliance is verified by tablets accounting, while in clinical practice this is not done)
doi: 10.1124/pr.108.00505 35 MenegazDHaganDWAlmaaJCianciarusoCRodriguez-DiazRMolinaJet al
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