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Synthesis of ROS-sensitive polymers (P1) To a solution of 1 h,1 h,10 h,10h-perfluoro-1,10-decanediol (0.62 g, 1.35 mmol) and ROS sensitive molecular (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 mL), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.63 g, 2.83 mmol) was quickly added

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Whilst most patients find that initial fatigue improves within 48 weeks as the body adapts, persistent or severe tiredness warrants medical review to exclude other causes and ensure safe continuation of treatment