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Combination with Metformin or Metformin with Sulfonylurea In a 30-week, open-label trial (NCT02128932), 1089 patients with type 2 diabetes mellitus were randomized to semaglutide 0.5 mg once weekly, semaglutide 1 mg once weekly, or insulin glargine once daily on a background of metformin (48%) or metformin and sulfonylurea (51%)
10.1177/17534666211016071 53 QueisserM
Crucially, they also act on receptors in the brainparticularly in areas regulating appetite and satietyto reduce hunger and increase feelings of fullness
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