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Beyond Obesity: Orforgliprons Expanding Pipeline In addition to its approved obesity indication, orforglipron is being investigated across a range of metabolic and cardiometabolic conditions, including type 2 diabetes, obstructive sleep apnoea, osteoarthritis knee pain, hypertension, peripheral artery disease, and stress urinary incontinence

The result is a compounding effect where genuine dehydration layers on top of medication-induced changes in salivary function