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Tirzepatides dual action sets it apart from medications like semaglutide (Wegovy or Ozempic): GLP-1 activity Increases the number of pancreatic betal cells Stimulates insulin secretion by beta cells Increases insulin sensitivity Increases clearance of triglycerides (a type of cholesterol) Breaks up fats Delays stomach emptying Acts on the brains appetite centers to promote fullness GIP activity Mainly acts on pancreas Decreases glucagon release by the pancreas Increases insulin release Promotes fat storage Supports the synthesis of glycogen People with type 2 diabetes often have abnormally low levels of GIP, or their pancreatic cells do not respond normally to GIP to release an adequate amount of insulin with food intake
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Pancreatitisinflammation of the pancreasand gastroparesis (severe stomach paralysis) are rare but serious conditions occasionally associated with GLP-1 therapy
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