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In summary, these data provide evidence that long-term IGF-1R blockade with mAbs is feasible, well tolerated, and can recapitulate effects observed with genetic disruption of IGF-1R signaling on lifespan
Insulin supplementation directly influences blood sugar levels by facilitating glucose uptake into the cells
Both mimic the hormone GLP-1, or glucagon like peptide 1 (tirzepatide mimics both GLP-1 and GIP, or gastric inhibitory polypeptide hormone) which controls the release of insulin from the pancreas and regulates blood sugar levels
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