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HbA1c fell about 2.0 to 2.6 percentage points and approached its floor by 10 mg, while weight continued responding to higher doses. Participants starting above 8% HbA1c often fell by more than 3 points
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Beyond their role in weight reduction, which itself can lessen mechanical friction and inflammation in intertriginous areas, GLP-1s improve insulin sensitivity, cardiometabolic risk factors, and may reduce systemic inflammationall of which can be more prevalent in HS patients
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