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In late 2024, Zealand Pharma initiated a phase 2b randomized dose-finding obesity and T2DM + obesity clinical trial (ZUPREME-1 and ZUPREME-2) which will evaluate petrelintides efficacy and safety in individuals with obesity in a larger population ( N = 480) [116]

While all GLP-1 medications may promote some weight loss, three drugs are specifically indicated for chronic weight management: Zepbound (tirzepatide) Wegovy (semaglutide) Saxenda (liraglutide) Multiple clinical trials have found that each of these medications can help people lose 5%-20% or more of their body weight though research suggests that some may be more effective than others