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In HG-induced MPC-5 and STZ-induced SD rat models, Icariin (ICA) can increase Sesn2-induced mitophagy via the Keap1-Nrf2/HO-1 axis, thereby inhibiting the activation of NLRP3 inflammatory vesicles and exerting a renoprotective effect [135]
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This review critically examines how liposomal technology protects glutathione from enzymatic breakdown and improves its biological availability, while also emphasizing the need for further clinical validation
Tirzepatide with B12: Benefits and Considerations
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