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Week 24: 6-Month Checkpoint Six months represents clinical trial checkpoint

For example, in HGC-27 cells, lactylation of METTL16 at lysine 229 promotes cuproptosis via m 6 A modification of the mRNA of ferredoxin 1 (FDX1), a key factor encoding a reductase known to convert Cu 2+ to its more toxic form Cu 1+ , indicating the promising therapeutic potential of targeting Kla and cuproptosis in cancer

However, despite sustained anti-PD-1/PD-L1 treatment, persistent T-cell dysfunction was observed, indicating that simply blocking these immune checkpoints may not be sufficient for achieving durable tumor regression