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Sources Holst JJ
Studies show that depression scores correlate to higher quinolinic acid in the blood, and postmortem studies show more cells in the brain producing quinolinic acid in suicide victims.[ref] Hepatitis C patients treated with interferon-alpha have depression and higher kynurenine metabolites.[ref] Another reason tryptophan metabolism could tilt more towards kynurenine is when the body is lacking in niacin
However, it appears that the weight-loss drugs may also alter the taste of said food
GLP-1 medications slow gastric emptying, which can change how quickly some oral drugs are absorbed, especially early in treatment and after dose increases
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