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It is imperative to acknowledge that, with the progressive exploration of lactylation, therapeutic strategies targeting lactylation may evolve from elucidating molecular mechanisms to achieving clinical application, ultimately transitioning from bench to bed
Ensuring absolute targeting specificity to the TME to preserve peripheral immunity remains a critical biodistribution challenge for these platforms (32)
Mult Scler 13:149 Linker RA, Gold R (2013) Dimethyl fumarate for treatment of multiple sclerosis: mechanism of action, effectiveness, and side effects
Western immunoblotting analyses indicated that the anti-ferroptotic proteins Gpx4, FSP1, and CoQ10 were upregulated in the TAC + PQQ group relative to the TAC group (Figure 2E)
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