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In a 12-week trial involving individuals with a BMI of 2743 kg/m, the highest-dose group achieved an 11.3% average weight reduction, a top-tier result for early-stage trials
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Although the use of targeted metabolite tracing, such as deuterium tracing of NADPH [7], is successful and remains the gold standard in the field, this approach requires mass-spectrometry, which may not be accessible to many laboratories
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