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By inhibiting sodium-glucose cotransporter-2 (SGLT-2), they inhibit glucose reabsorption in the kidneys, resulting in increased urinary glucose excretion
in vivo, hypercoagulation decreased upon LC treatment (ElGendy 2014): hypothesized
The ATTAIN program encompasses multiple Phase 3 trials in obesity (ATTAIN-1, ATTAIN-2, ATTAIN-3, ATTAIN-MAINTAIN), while the ACHIEVE program covers type 2 diabetes indications (ACHIEVE-1 through ACHIEVE-5, plus regional studies)
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