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Of note, injectable FSH is necessary in this situation as SERMs/anastrazole will not stimulate FSH production from the pituitary in the face of TRT

Current first-line treatments for PCOS typically include lifestyle modifications, metformin for insulin resistance, and hormonal contraceptives for menstrual regulation

After acute brain injury, the activation of oxidative stress and inflammatory reactions results in the buildup of intracellular iron, subsequently triggering ferroptosis (Shen et al., 2020)

We hope that in the future, more researchers will focus on more basic research on HO-1 in DN, including its expression regulation, mechanism of action, and interaction with other molecules