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GLP-1 receptor agonists are primarily licensed for type 2 diabetes mellitus and obesity management, not hypertension treatment

This proves that GLP-1 promotes the activity of PI3 K in -cell, which is connected with myocardial protection in ischaemia/reperfusion injury through antiapoptotic effect

Hormonal Shifts : Tirzepatide affects hormones like insulin and glucagon, which may indirectly influence cortisol and melatonin levelstwo key players in sleep regulation

33 An international phase III RCT (RESOLVE-IT, NCT02704403) comparing elafibranor with placebo in NASH patients was terminated early due to insignificant efficacy but without significant adverse events at 72 weeks of treatment