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Many patients simply do not feel the need to drink enough water throughout the day

To counteract the oxidative stress damage by maintaining cellular redox balance, bacteria L-forms demonstrate upregulated expression of genes encoding antioxidant enzymes (e.g., catalase and superoxide dismutase) and genes associated with oxidative stress response (e.g., arcB , ompC , and sosR ) [46]

As noted above, the low level of the T4 and/or T3 loops back to the brain to signal it to raise the level of TSH, which functions to stimulate the thyroid to make more T3/T4

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