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Despite this relatively short half-life in circulation, the downstream metabolic effects persist for significantly longer due to the sustained activation of lipolytic enzymes and metabolic pathways initiated by the peptide
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For example, a 2021 study on semaglutide showed an average weight loss of around 15% in obese individuals over 68 weeks on maximum dose of semaglutide, compared to a placebo groups 2.4%
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