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The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts
Risks include melanoma (skin cancer) and long, painful erections, says the FDA
Microdoses are dramatically below any clinically tested level, sometimes as low as 0.05 to 0.1mg
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