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In this context, the emergence of new molecules capable of effectively treating obesity and associated metabolic comorbidities offers a valuable opportunity for broadening therapeutic strategies in PsD patients
Hyperglycemia increases diacylglycerol (DAG) synthesis, which activates these PKC isoforms in renal tissues, leading to upregulation of profibrotic cytokines such as transforming growth factor-beta (TGF-) and increased production of extracellular-matrix proteins including collagen and fibronectin
In 2014, Kacem et al
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