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In hepatic encephalopathy, elevated blood ammonia resulting from liver failure disrupts the BBB via the Nuclear Factor -Light-Chain-Enhancer of Activated B Cells (NF-B) pathway, impairs mitochondrial function in astrocytes, and perturbs neurotransmitter balance through potassium dysregulation [67]
This plays a significant role in appetite regulation and gut hormone signalling
Effect of starvation on transcriptomes of brain and liver in adult female zebrafish ( Danio rerio )
References [1] Saravanan P, Siddique H, Simmons D, Greenwood R, Dayan C
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