Mayo Clinic Proceedings 90(9): 12331246 [PubMed] [PMC] Street ME, Angelini S, Bernasconi S, Burgio E, Cassio A, Catellani C, Cirillo F, Deodati A, Fabbrizi E, Fanos V, Gargano G, Grossi E, Iughetti L, Lazzeroni P, Mantovani A, Migliore L, Palanza P, Panzica G, Papini AM, Parmigiani S, Predieri B, Sartori C, Tridenti G, Amarri S (2018) Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: highlights from a National Italian Meeting
Where the FDA approves these medications for adults with a BMI of 30, or a BMI of 27 with a weight-related comorbidity, the Bridge sets specific BMI thresholds paired with a defined list of qualifying conditions
Therefore, the measured pKa may vary in different solvents
Hypersensitivity to the formulation constitutes another contraindication[13]