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It triggers pulsatile GH release without substantially increasing ACTH or cortisol in preclinical work, and has been investigated in human trials for safety in specific clinical settings
Metformin remains first-line therapy, improving hepatic insulin sensitivity and reducing glucose production
Diagnosis is typically confirmed through blood tests showing elevated thyroid-stimulating hormone (TSH) levels and reduced free T4
Another important effect of secretin is the stimulation of insulin secretion from -cells of the pancreas in response to the ingestion of glucose
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