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Functional studies deplete cellular glutathione using buthionine sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, to create controlled oxidative stress models

Parihar VK, Limoli CL (2013) Cranial irradiation compromises neuronal architecture in the hippocampus

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Research designs using this combination can dissect the relative contributions of GLP-1 receptor versus amylin receptor pathways to observed metabolic effects valuable mechanistic data for understanding the full pharmacology of each pathway