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Moreover, sitagliptin reduced TNF or LPS-induced cellular reactive oxygen species (ROS) level, cell apoptosis, and protein expression in the NFB signaling pathway in HepG2 cells or primary mouse hepatocytes
Effects on classic cardiovascular risk factors CVOTs on GLP-1RAs Data from the major CVOTs ELIXA, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, LEADER, REWIND, and AMPLITUDE-O [53, 54, 56, 59,60,61,62,63] support the overall safety of GLP-1RAs relative to major cardiovascular outcomes
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