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10.1007/s00424-018-2190-4 8 BalakumarP.AlqahtaniA.KhanN
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9 Mechanisms of nanomedicine regulating immune cells The physicochemical properties of drug-loaded nanomaterials along with the drugs they carry collectively determine their regulation of immune cells, the mechanisms may involve indirect regulation of immune cells (such as inducing tumor cells to undergo ICD, ferroptosis, or pyroptosis, and targeting tumor-derived exosomes) and direct regulation of immune cells (through activation of the cGAS-STING, NF-Kb, and mTOR pathways, as well as inhibition of SHP2, CD73, or glutaminase)
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