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(PubMed) Kristal AR, Darke AK, Morris JS, et al
For instance, in the MYD88-dependent TLR pathway, IRAK1 undergoes phosphorylation and interacts with TRAF6, leading not only to the activation of the NF-B inhibitor (IB) kinase (IKK) complex but also to the stimulation of MAPKs such as JNK and p38 MAPK
ROS can stimulate the NF-B pathway, leading to the production of pro-inflammatory cytokines and chemokines 80
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