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The mechanism behind this hyperpigmentation involves the increased production of melanocyte-stimulating hormone (MSH) and other pro-opiomelanocortin byproducts
The evidence base for GLP-1 receptor agonists in post-bariatric weight regain continues to expand, though large randomized controlled trials remain limited compared to primary obesity treatment
However, no clinical trials have evaluated this combination, and any multi-peptide or peptide-plus-GLP-1 protocol should be managed by a practitioner who can monitor labs, adjust doses, and watch for unexpected interactions
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