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The primary difference is in their primary area of effect
Save Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i) and Glucagon-like peptide-1 receptor agonists (GLP1-RA) were initially developed as glucose-lowering agents for the treatment of Type 2 Diabetes
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It should also be noted that an oral form of semaglutide was developed by adding an agent to the drug formulation, which increases intestinal permeability, sodium N-(8-(2-hydroxybenzoyl)amino)caprylate (SNAC), but the lower bioavailability of the molecule requires daily administration to achieve glycemic control equivalent to that obtained by the form administered subcutaneously
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