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Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy

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The use of claim 28 wherein the peptide Ac-Nle-cycVo(-Asp-His-D-Phe-Arg-Trp-Lys)- OH is employed for manufacture of a medicament for treatment by nasal administration and the PDE-5 inhibitor is employed for manufacture of a medicament for treatment by oral administration