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22 Compared with the control group, liraglutide also significantly increased activation of the dorsolateral prefrontal cortex and orbitofrontal cortex brain regions ( P = .0038)

GIP receptor activation enhances insulin secretion, modulates adipose tissue metabolism, and appears to synergise with GLP-1 activity to produce greater metabolic effects than either hormone alone as demonstrated by the clinical performance of the dual agonist tirzepatide

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