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Johnson et al., 2019), limited information is available regarding bioenergetics within the cerebrovasculature, particularly in relation to both FA uptake and fatty acid oxidation (FAO) capabilities within the context of aging and different APOE genotypes, despite the fact that cerebrovascular FAO has been suggested to be an essential process in maintaining its transport functions (Goldstein, 1979)
In astrocytes lacking GLP-1R, the increase in FGF21 is associated with improved systemic glucose homeostasis and memory formation
The accessibility and equitable distribution of GLP-1 receptor agonists remain challenging with high costs, limited insurance coverage, and geographic disparities creating barriers to access, particularly affecting those in healthcare deserts or demographics with lower healthcare outcomes (Azizi et al., 2024
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