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A pharmacophore model from the 5UOY16j complex was used to screen the ZINC database, yielding 11,126 hits, which were narrowed down to 4 candidates, namely, compounds 23 , 24 , 25 , and 26 (ZINC00552773, ZINC75914738, ZINC73091800, and ZINC15933417) using Lipinskis rule, the PFS filter, and the SwissADME server (Figure 8)

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E imediatamente o Paraguai comeou a importar isso, os importadores paraguaios comearam a trazer e os prprios laboratrios paraguaios a desenvolverem a partir de princpios ativos importados

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