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Moreover, no studies have been undertaken in controlled circumstances to demonstrate whether a reduction in sulphotransferase activity causes increased paracetamol oxidation or increased propensity to paracetamol toxicity at either therapeutic or supra-therapeutic doses

However, evidence showing that visfatin can exert its effects independently of TLR4 [193] suggests that yet unidentified receptors could be involved in these mechanisms

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Furthermore, endothelial dysfunction and the presence and severity of coronary artery disease are positively associated with glucose variability in patients with T2DM