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Kappe et al., 2013
The analysis revealed significant alterations in protein structures, supporting the classification of these variants as pathogenic (Table 4)
From there, the dose may increase to 5 mg, 7.5 mg, and eventually up to 15 mg if needed
Mechanistically, we found that MYTHO/ myt-1 played a critical role in autophagy regulation and particularly, in WIPI2-ATG16L and ATG7 recruitment on the phagophore under stress conditions
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